Sennoside B NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Sennoside B | CAS No.: 128-57-4 |
| Purity: 97.35% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Sennoside B |
| Description | Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation. |
| In vitro | Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). [2] It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM. [1] |
| In vivo | LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.). [3] |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 10 mg/mL (11.59 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. H2O : Insoluble DMSO : 125 mg/mL (144.89 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 10 mg/mL (11.59 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| Keywords | Sennoside B | Platelet-derived growth factor receptor | PDGFR | Inhibitor | inhibit |
| Inhibitors Related | Regorafenib monohydrate | Sunitinib | Nintedanib | Imatinib Mesylate | Toceranib Phosphate | Sorafenib | Nintedanib esylate | Regorafenib | Lenvatinib mesylate | Lenvatinib | Pazopanib | Axitinib |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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