SHP2-IN-8 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: SHP2-IN-8 | CAS No.: 1801692-60-3 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | SHP2-IN-8 |
| Description | SHP2-IN-8 is a reversible, noncompetitive, selective and efficient allosteric SHP2 inhibitor (IC50=23 nM, Ki=22 nM), which also has effects in cells. SHP2-IN-8 can cause significant thermal displacement( Δ Tm = 7.01 ℃). SHP2-IN-8 can inhibit the phosphorylation of AKT and induce apoptosis of Hela cells. |
| In vitro | SHP2-IN-8 (compound TK-453), at concentrations from 0 to 100 μM over 48 hours, shows moderate inhibitory effects on KYSE-70, Hela, and THP-1 cell proliferation. At 0 to 30 μM for 24 hours, it induces dose-dependent apoptosis in Hela cells. Within 0 to 2 hours at 0 to 30 μM, SHP2-IN-8 inhibits AKT phosphorylation in Hela and KYSE-70 cells in a concentration- and time-dependent manner. These effects were confirmed using Cell Proliferation Assay, Apoptosis Analysis, and Western Blot Analysis, highlighting the compound's impact on cell growth, apoptosis, and AKT pathway inhibition in the tested cell lines [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Ethyl linoleate | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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