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Postion:Product Catalog >Siglec-E Protein, Mouse, Recombinant (hFc)
Siglec-E Protein, Mouse, Recombinant (hFc)
  • Siglec-E Protein, Mouse, Recombinant (hFc)

Siglec-E Protein, Mouse, Recombinant (hFc) NEW

Price $3280
Package 1mg
Supply Ability: 10g
Update Time: 2026-05-04

Product Details

Product Name: Siglec-E Protein, Mouse, Recombinant (hFc) Purity: Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Supply Ability: 10g Release date: 2026/05/04

Product Introduction

Bioactivity

NameSiglec-E Protein, Mouse, Recombinant (hFc)
DescriptionSiglecs are sialic acid specific I?type lectins that are characterized by an extracellular domain (ECD) with an N?terminal Ig?like V?set domain followed by varying numbers of Ig?like C2?set domains. Mouse Siglec?E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 ? 85 kDa member of the CD33?related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec?9 is the most likely human ortholog of mouse Siglec?E. Siglec?E is expressed as a heavily N?glycosylated disulfide?linked homodimer and shows binding preference for disialic acids in the alpha 2?8 linkage. Siglec?E is up?regulated and additionally phosphorylated following cellular stimulation by a variety of TLR agonists. Siglec?E signaling negatively regulates the LPS?induced production of TNF? alpha and IL?6 by macrophages. Its up?regulation in macrophages parallels the development of endotoxin tolerance. Siglec?E recognition of sialylated determinants on virulent T. cruzi contributes to the suppression of dendritic cell IL?12 p40 production.
StorageLyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months Shipping with blue ice/Shipping at ambient temperature.

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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