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Postion:Product Catalog >Chemical Reagents>Organic reagents>Polycyclic compound>Simurosertib
Simurosertib
  • Simurosertib

Simurosertib NEW

Price $59 $162 $226
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: Simurosertib CAS No.: 1330782-76-7
Purity: 99.98% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameSimurosertib
DescriptionSimurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).
In vitroSimurosertib effectively inhibits CDC7 kinase activity (IC50 <0.3 nM) with time-dependent ATP-competitive kinetics to its ATP-binding pocket. Treatment with Simurosertib inhibits the cellular MCM2 phosphorylation at Ser40 in a dose-dependent manner, resulting in a delayed S phase progression, DNA-damage checkpoint activation, and caspase-3/7 activation. The selectivity studies using the 308 kinases reveals >120-fold selectivity of Simurosertib for CDC7 kinase inhibition compared to other kinase inhibitions [1].
In vivoSimurosertib (p.o.) inhibits pMCM2 of the xenografted COLO205 in a dose- and time-dependent manner in the COLO205-xenograft mouse model. Simurosertib shows a significant antitumor activity in multiple xenograft models [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+90% Saline : 4.7 mg/mL (13.77 mM), Suspension.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (14.64 mM), Solution.
DMSO : 47 mg/mL (137.66 mM), Sonication is recommended.
KeywordsTAK931 | TAK 931 | Simurosertib | orally | Inhibitor | inhibit | division | Cyclin dependent kinase | cycle | cell | CDK | Cdc7 | ATP-competitive | anti-cancer
Inhibitors RelatedRibociclib | (E)-β-Farnesene | Amantadine | 2-Chloropyrazine | Kojic acid | Abemaciclib | Palbociclib | Abemaciclib methanesulfonate | Sodium Oxamate | Seliciclib | 2,4,6-Trihydroxybenzoic acid | Dinaciclib
Related Compound LibrariesBioactive Compound Library | ReFRAME Related Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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