Sipagladenant NEW
| Price | $766 | $995 | $1740 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Sipagladenant | CAS No.: 858979-50-7 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Sipagladenant |
| Description | Sipagladenant (Compound I) is an orally active inverse agonist of the adenosine receptor A2A [1], with potential applications in research on frontal lobe dysfunction [2]. |
| In vivo | Sipagladenant administered orally at a dosage of 0.3 mg/kg significantly improves cognitive impairment associated with reduced dopamine function in the medial prefrontal cortex, evident through enhanced exploratory behavior towards novel objects (65.03% exploration time) in comparison to familiar ones (34.97%) [2]. Similarly, at a lower dosage of 0.1 mg/kg, Sipagladenant demonstrates an ability to enhance cognitive function, as shown by a notable increase in alternation behavior in ICR mice with cognitive impairment and/or movement disorder [2]. Moreover, this lower dosage also leads to significant improvements in gait parameters, including a larger maximum contact area and gait area of the left hindpaw compared to controls, alongside a tendency for increased contact and gait area in the right forepaw, highlighting its potential in ameliorating mobility-related symptoms [2]. These findings are based on studies conducted in medial prefrontal dopaminergic terminal-lesioned CD(SD) IGS male rats and ICR mice models, indicating Sipagladenant's broad therapeutic potential across different animal models of neurological impairment. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Xanthine | Theophylline monohydrate | Diphylline | Adenosine monophosphate | Acefylline | Sulcatone | Adenosine 5'-monophosphate monohydrate | Inosine | Theobromine | Adenosine 5'-monophosphate disodium salt | Theophylline | Doxofylline |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:92586-35-1
-
-
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1.50 |
VIP5Y
|
Shaanxi Didu New Materials Co. Ltd
|
2026-05-21 | |
|
VIP2Y
|
Xi an Biohorlden Industry Trade Co Ltd
|
2026-07-03 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY