SLLN-15 NEW
| Price | $2140 | $2785 | $3520 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-30 |
Product Details
| Product Name: SLLN-15 | CAS No.: 2403650-93-9 |
| Supply Ability: 10g | Release date: 2025/07/30 |
Product Introduction
Bioactivity
| Name | SLLN-15 |
| Description | SLLN-15 is an orally active, selective, and potent enhancer of autophagy, activating cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC) [1]. |
| In vitro | Treatment with SLLN-15 at concentrations of 0, 1, 5, 10, and 25 μM for 24 hours significantly decreases the viability of breast cancer cells in a dose-dependent manner, demonstrating its potency against these cells [1]. Similarly, SLLN-15 administered at 100 nM and 1000 nM for 7 days effectively inhibits the colony formation abilities across various breast cancer cell lines, including TNBC (triple-negative breast cancer) lines like MDA-MB-231 and BT-20, without discrimination [1]. SLLN-15 exercises its anti-proliferative effects on TNBC cell lines MDA-MB-231 and BT-20, predominantly through the induction of autophagy and autophagic flux. This action corresponds with a specific inhibition of the AKT-MTOR signaling pathway, further establishing its targeted mechanism in reducing cell viability and proliferation in these cancer cells. |
| In vivo | SLLN-15 (30mg/kg, PO, 3 times a week) effectively suppresses triple-negative breast cancer (TNBC) growth and hinders metastasis in animal models, demonstrating significant anti-cancer and anti-metastatic properties. In BALB/c or SCID mice implanted with 1 X 10^6 mouse 4T1 or human MDA-MB-231 cells [1], SLLN-15 markedly slowed tumor growth and reduced lung metastases compared to controls [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SLLN 15 | SLLN15 | SLLN-15 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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