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Postion:Product Catalog >SM1-71
SM1-71
  • SM1-71

SM1-71 NEW

Price $44
Package 2mg
Supply Ability: 10g
Update Time: 2026-06-01

Product Details

Product Name: SM1-71 CAS No.: 2088179-99-9
Purity: 96.00% Supply Ability: 10g
Release date: 2026/06/01

Product Introduction

Bioactivity

NameSM1-71
DescriptionSM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines.
In vitroPotently inhibiting the proliferation of H23 and Calu-6 non-small cell lung cancer cell lines in a concentration-dependent manner, SM1-71 (0.001-100 μM; 72 h) demonstrates its efficacy. Additionally, SM1-71 induces potent cytotoxicity within 72 hours, with nanomolar values for GR50 and negative GRmax values observed in eight of 11 cancer cell lines[1][2].
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 100 mg/mL (215.54 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (8.62 mM), Sonication is recommended.
Keywordsthreoninkinase | threonin kinase | TGF-β/Smad | TGFβ | TGFbeta/Smad | TGF-beta | TGFbeta | TGF-b/Smad | TGFb | TAK1 | Smad | SM-1-71 | SM171 | SM1 71 | Serinekinase | Serine/threonin kinase | Serine kinase | MAP3K | LIMKinase | LIMK1 | LIM Kinase | bone morphogenetic protein (BMP) | AP2associatedkinase1 | AP2 associated kinase 1 | AAK1(AP2associatedkinase1) | AAK1 (AP2 associated kinase 1) | AAK1
Inhibitors RelatedMelamine | Amlexanox | Hydrochlorothiazide | Ferulic Acid | Dasatinib | Ibrutinib | Nintedanib esylate | Formononetin | Pirfenidone | Lenvatinib | Pazopanib | Sodium new houttuyfonate
Related Compound LibrariesHIF-1 Signaling Pathway Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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