SNIPER(ER)-87 NEW
| Price | $1980 |
| Package | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: SNIPER(ER)-87 | CAS No.: 2222354-91-6 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | SNIPER(ER)-87 |
| Description | SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effectively degrades the ERα protein with an IC50 value of 0.097 μM. Within cells, SNIPER(ER)-87 selectively recruits XIAP to ERα, and XIAP functions as the primary E3 ubiquitin ligase responsible for the degradation of ERα induced by SNIPER(ER)-87[1][2]. |
| In vitro | SNIPER(ER)-87, at concentrations ranging from 0.1 to 1000 nM over 72 hours, effectively suppresses ERα-dependent transcriptional activation induced by β-estradiol and inhibits the proliferation of ERα-positive breast cancer cells, achieving IC50 values of 15.6 nM in MCF-7 cells and 9.6 nM in T47D cells[1]. |
| In vivo | SNIPER(ER)-87, administered intraperitoneally at a dosage of 30 mg/kg every 24 hours for a duration of 14 days, effectively suppresses the development of MCF-7 orthotopic breast tumor xenografts in six-week-old female BALB/c nude mice[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SNIPER(ER)-87 | SNIPER(ER)87 | SNIPER(ER) 87 |
| Inhibitors Related | Tamoxifen | Estradiol | 2-Ethylhexyl trans-4-methoxycinnamate | Diisopropyl phthalate | Estradiol benzoate | Bisphenol B | Mequinol | Phthalic acid | Chlorothalonil | Ethisterone | Tamoxifen Citrate | Cholesterol |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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