sodium glycocholate

Modify Date: 2024-01-02 10:54:40

sodium glycocholate structure	Common Name	sodium glycocholate
	CAS Number	863-57-0	Molecular Weight	487.604
	Density	N/A	Boiling Point	692oC at 760 mmHg
	Molecular Formula	C26H42NNaO6	Melting Point	210-215 °C (subl.)(lit.)
	MSDS	N/A	Flash Point	372.3oC

Purity		Quantity		Budget		Inquiry

Use of sodium glycocholate Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].

• Properties

• Spectrum

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 Names

Name	sodium glycocholate
Synonym	More Synonyms

 sodium glycocholate Biological Activity

Description	Glycocholic acid sodium is an orally active bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
Related Catalog	Research Areas >> Others
Target	Microbial Metabolite Human Endogenous Metabolite
In Vitro	Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1].

 Chemical & Physical Properties

Boiling Point	692oC at 760 mmHg
Melting Point	210-215 °C (subl.)(lit.)
Molecular Formula	C26H42NNaO6
Molecular Weight	487.604
Flash Point	372.3oC
Exact Mass	487.290985
PSA	129.92000
LogP	1.62110
Index of Refraction	30 ° (C=1, H2O)
Storage condition	Refrigerator

 MSDS

Material Safety Data Sheet Section1. Identi?cation of the substance Product Name: Sodium glycocholate Synonyms: Section2. Hazards identi?cation Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Sodium glycocholate CAS number:863-57-0 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate ?ushing of the eyes by separating the eyelids with ?ngers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire ?ghting measures In the event of a ?re involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly quali?ed in the handling and use of potentially hazardous chemicals, who should take into account the ?re, health and chemical hazard data given on this sheet. Storage:Store in closed vessels, refrigerated. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not speci?ed Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula: C26H42NO6.Na Molecular weight: 487.6 Section10. Stability and reactivity Conditions to avoid: Heat, ?ames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

 Toxicological Information

CHEMICAL IDENTIFICATION RTECS NUMBER : MB9265100 CHEMICAL NAME : Glycine, N-choloyl-, monosodium salt CAS REGISTRY NUMBER : 863-57-0 LAST UPDATED : 199404 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C26-H43-N-O6.Na MOLECULAR WEIGHT : 488.69 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TEST SYSTEM : Rodent - rat DOSE/DURATION : 400 mg/kg REFERENCE : JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80519 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

 Safety Information

Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	MB9265100

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