Sonidegib diphosphate NEW
| Price | $43 | $52 | $83 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Sonidegib diphosphate | CAS No.: 1218778-77-8 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Sonidegib diphosphate |
| Description | Sonidegib diphosphate (LDE225 diphosphate) is a selective antagonist of Smo that inhibits murine Smo (IC50:1.3 nM) and human Smo (IC50:2.5 nM). |
| In vitro | METHODS: Sonidegib diphosphate (LDE225 diphosphate) (10, 100nM, 72 hours) was treated in CD34 CP-CML cells and its effect on GLI1 expression in CD34 CP-CML cells was assessed. RESULTS No changes in GLI1 were observed in CD34 CP-CML cells at 6 and 24 h; at 72 h, GLI1 was significantly downregulated (10 nM; 0.78-fold and 100 nM; 0.73-fold). [2] |
| In vivo | METHODS: A transgenic EGFP/SCLtTA/TRE-BCR-ABL mouse model was used, and mice were treated with nilotinib (50 mg/kg, gavage, daily, 3 weeks), Sonidegib diphosphate (LDE225 diphosphate) (80 mg / kg, gavage, daily, 3 weeks), Sonidegib diphosphate (LDE225 diphosphate) + nilotinib, or carrier alone (control) treatment, to study the effects of Sonidegib diphosphate (LDE225 diphosphate) treatment on CML LSC in vivo. RESULTS The cohort treated with Sonidegib diphosphate (LDE225 diphosphate) had a small, non-significant incremental reduction in mean body weight; Sonidegib diphosphate (LDE225 diphosphate) alone reduced splenic LTHSC but did not significantly reduce GMP and CMP ; Sonidegib diphosphate (LDE225 diphosphate) + nilotinib significantly reduced GMP, CMP, and LTHSC in the spleen. in contrast, in the BM of mice treated with Sonidegib diphosphate (LDE225 diphosphate), nilotinib, or the combination there were no significant changes in the amounts of GMP, CMP and LTHSC. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 99 mg/mL (145.27 mM), Sonication is recommended. H2O : Insoluble 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (4.84 mM), Sonication is recommended. |
| Keywords | Sonidegib | Smo | NVP-LDE-225 Diphosphate | NVP-LDE-225 | NVP-LDE225 | NVP-LDE 225 | mSmo | LDE-225 Diphosphate | LDE-225 | LDE225 | LDE 225 Diphosphate | LDE 225 | hSmo | Erismodegib |
| Inhibitors Related | IHR-1 | ALLO-2 | Purmorphamine | LEQ506 | Halcinonide | MRT-83 | BMS-833923 | SAG | Sonidegib | SMO-IN-2 | Jervine | MK-4101 |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1520.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-04-21 | |
|
VIP2Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2026-05-20 | ||
|
VIP6Y
|
RongNa Biotechnology Co.,Ltd
|
2026-06-07 | ||
| $1.00 |
VIP7Y
|
Career Henan Chemical Co
|
2020-01-13 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY