Spiramycin NEW
| Price | $40 |
| Package | 500mg |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Spiramycin | CAS No.: 8025-81-8 |
| Purity: 97.92% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Spiramycin |
| Description | Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens, effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci, and is used to treat infections caused by bacteria and Toxoplasma gondii. |
| In vivo | Spiramycin acts by binding to the bacterial 50S ribosomal subunit, thereby inhibiting translocation. Its primary mechanism during translocation involves stimulating the dissociation of peptidyl-tRNA from the ribosome. The compound reduces the protective effect of anisomycin on 23S rRNA nucleotides. Spiramycin exhibits potent antibacterial activity against the genus Prevotella, Streptococcus mitis, Archaea, strains of Porphyromonas, and Bacteroides, with metronidazole enhancing its efficacy. At 30°C, Spiramycin can inhibit protein synthesis in wild-type cells but not kill mutant or wild-type cells. Treating lipopolysaccharide-stimulated human monocytes with Spiramycin and erythromycin increases the total production of IL-6 without affecting TNFα, IL-1α, or IL-1β production. Spiramycin inhibits protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. It dose-dependently inhibits the proliferative response of human mononuclear cells stimulated by pulse-width modulation and polyhydroxyalkanoate esters. Additionally, Spiramycin induces a reduction in tritiated thymidine uptake, suggesting interference with an early stage of the cell cycle. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 93 mg/mL (110.31 mM), Sonication is recommended. Ethanol : 93 mg/mL (110.31 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Spiramycin | Parasite | Bacterial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Kojic acid | Methyl anthranilate | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Hydroxychloroquine | Doxycycline | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Natural Product Library | Saccharide and Glycoside Natural Product Library | Microbial Natural Product Library | Antiparasitic Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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