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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>SQ109
SQ109
  • SQ109

SQ109 NEW

Price $50 $118 $182
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-15

Product Details

Product Name: SQ109 CAS No.: 502487-67-4
Purity: 99.91% Supply Ability: 10g
Release date: 2026/05/15

Product Introduction

Bioactivity

NameSQ109
DescriptionSQ109 (NSC 722041) is an ethambutol (EMB) derivative and a specific inhibitor of MmpL3, exhibiting potent anti-Mycobacterium tuberculosis activity. SQ109 effectively inhibits the adult stage of the parasite Trypanosoma and kills cells, with an IC50 of 50 ± 8 nM. SQ109 can be used in tuberculosis and antiparasitic research.
In vitroMethods: Peritoneal macrophages from mice were infected with M.tb H37Rv (MOI 1:10). After infection, cells were treated with SQ109 (5 μM, 10 μM) for 24 hours, lysed, and plated for CFU counting. Results: SQ109 concentration-dependently reduced intracellular viable bacteria, confirming its ability to enhance macrophage killing of M.tb. [1]
In vivoMethods: C57BL/6J mice were aerosol-inoculated with a low dose of M.tb H37Rv (110 CFU/lung). Starting on day 15 post-infection, SQ109 (10 mg/kg body weight) was administered via intraperitoneal injection daily until the euthanasia time points (days 22 and 35 post-infection). Results: SQ109 significantly reduced bacterial load in lungs and spleen. Lung histopathology revealed decreased inflammatory and necrotic lesions. [1] Methods: New Zealand White rabbits were infected with M.tb H37Rv to form humanized tuberculous granulomas with cellular margins and caseous necrosis cores. SQ109 was administered at 40 mg/kg daily for 7 consecutive days. Plasma, lung tissue, isolated cellular lesion areas, and caseous necrosis foci were collected for drug concentration measurement. Results: SQ109 accumulates extensively in lung tissue and areas of cellular lesions, with a penetration coefficient >1000. Passive diffusion is slow in caseous necrosis lesions, and drug concentrations are low, suggesting that several weeks of administration are required to achieve steady state.[2]
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.05 mM), Sonication is recommended.
DMSO : 21 mg/mL (63.53 mM), Sonication is recommended.
Keywordstrypomastigote cell | SQ-109 | SQ109 | SQ 109 | Parasite | NSC-722041 | NSC722041 | MmpL3 | Inhibitor | inhibit | Bacterial | Antibiotic
Inhibitors RelatedNeomycin sulfate | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | 2-Amino-2-methyl-1-propanol | Fenpyroximate | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate
Related Compound LibrariesFailed Clinical Trials Compound Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Bacterial Compound Library | Orally Active Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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