Product Details
| Product Name:
SR-31747 |
CAS No.:
132173-07-0 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | SR-31747 |
| Description | SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties. |
| In vitro | SR-31747 (10 nM) blocks the proliferation of lymphocytes at a concentration. SR-31747 arrests proliferation in yeast cells in a dose-dependent manner. SR-31747 is capable of inhibiting T-cell proliferation when added as late as 24 h after activation [2]. |
| In vivo | SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6, and TNF-α in a dose-dependent manner (ED50: 2 mg/kg) in vivo. SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. Ablation of corticosteroids by the use of Mifepristone or adrenalectomy suppresses the effect of SR-31747. Administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxic shock as a result of monokine inhibition [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 15.62 mg/mL (39.4 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 1.5 mg/mL (3.78 mM), Sonication is recommended.
|
| Keywords | SR-31747 | SR31747 | SR 31747 | Sigma ligand |
| Inhibitors Related | Amitriptyline | Cutamesine dihydrochloride | Opipramol | L-693,403 maleate | Noscapine | Oxeladin citrate | Amitriptyline hydrochloride | S1R agonist 2 | 4-PPBP maleate | Glycerol phenylbutyrate | Sigma-1 receptor antagonist 1 | AB21 HCl |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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