(S,R,S)-AHPC-PEG2-C4-Cl NEW
| Price | $61 | $98 |
| Package | 2mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: (S,R,S)-AHPC-PEG2-C4-Cl | CAS No.: 1835705-57-1 |
| Supply Ability: 10g | Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | (S,R,S)-AHPC-PEG2-C4-Cl |
| Description | (S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC, comprising the (S,R,S)-AHPC based VHL ligand and a 2-unit PEG linker, that induces the degradation of GFP-HaloTag7 in cell-based assays[1]. |
| In vitro | (S,R,S)-AHPC-PEG2-C4-Cl employs the VHL ligand to facilitate the development of PROTACs targeting the oncogenic tyrosine kinase BCR-ABL, using a 6-2-2 linker that balances hydrophobicity and hydrophilicity. This compound can conjugate with potent tyrosine kinase inhibitors (TKIs) like bosutinib and dasatinib to promote the degradation of c-ABL and BCR-ABL via CRBN or VHL E3 ubiquitin ligase mechanisms. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (76.77 mM), Sonication is recommended. |
| Keywords | VHL | AHPC-PEG2-C4-Cl | (S,R,S)-AHPC-PEG-2-C4-Cl | (S,R,S)AHPCPEG2C4Cl | (S,R,S) AHPC PEG2 C4 Cl |
| Inhibitors Related | Pomalidomide-PEG4-Ph-NH2 | Pomalidomide 4'-alkylC3-acid | Bavdegalutamide | (S,R,S)-AHPC | dBET6 | Dbet57 | ZNL 02-096 | ARV-825 | TGN-020 | AU-15330 | Vepdegestrant | 5-Aminothalidomide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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