Product Details
| Product Name: SUBSTANCE P | CAS No.: 33507-63-0 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 100kg | Release date: 2026/04/17 |
| Lead time: in stock | Packaging: bag/bottle/drum//IBC, as request |
| Delivery: By sea, by air, by express | Origin: Manufacturer, advantage products |
| COA, MSDS: Available, contact us for details | Contact: Tina |
PRODUCT INFORMATION
| Name | Substance P |
|---|---|
| Synonym | More Synonyms |
| Description | Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. |
|---|---|
| Related Catalog | Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Natural Products >> Others Peptides |
| Target | Human Endogenous Metabolite |
| In Vitro | The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1]. |
| References | [1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24. [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C63H98N18O13S |
| Molecular Weight | 1347.630 |
| Exact Mass | 1346.728149 |
| PSA | 544.43000 |
| LogP | -0.85 |
| Index of Refraction | 1.663 |
| Storage condition | ?20°C |
| Water Solubility | H2O: 1 mg/mL | Soluble in water, DMSO, and Acetic Acid. |
| WGK Germany | 3 |
|---|
 Chloromethane CAS#:74-87-3  N/A CAS#:98264-76-7 ~%  Substance P ace... CAS#:33507-63-0 |
| Literature: Tetrahedron Letters, , vol. 26, # 5 p. 623 - 626 |
 Boc-Gly-OH CAS#:4530-20-5  Boc-Leu-OH.H2O CAS#:13139-15-6  Boc-Met-OH CAS#:2488-15-5  Boc-L-phenylalanine CAS#:13734-34-4 ~% Detail |
| Literature: Journal of Medicinal Chemistry, , vol. 25, # 1 p. 64 - 68 |
| Precursor 5 | Previous 1/2 Next |
|---|---|
| |
| DownStream 0 | |
| UNII:675VGV5J1D |
| R-Phg-S-Leu |
| N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide |
| Aminophenylacetylleucine |
| L-Methioninamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- |
| D-phenylglycyl-L-leucine |
| H-RPKPQQFFGLM-NH2 |
| Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| neuropeptide substance P |
| RPKPQQFFGLM-NH2 |
| RPKPQQFFGLM |
| EINECS 251-545-8 |
Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
Our Company
Our Advantage
Rich experience
Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.
Excellent quality, purity, and competitive price
Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.
Safe and fast delivery
We will arrange shipment of spot products as soon as we receive payment.
Customized products are determined based on the synthesis time of different products.
Excellent pre-sales and after-sales service
Pre sales:
We are committed to providing the most favorable quotes and detailed information about our products and company.
after-sale service:
We assist buyers in customs clearance by providing necessary documents and information.
If there is any dispute over product quality, we are committed to providing the best solution.
? Packaging:
1kg/bag, 25kg/drum, 50kg/drum, 180kg/drum, 200kg/drum, 1T/bag/drum, standard export packaging or packaging required by customers
? Shipping
? Delivery:
Within 7 days after receiving your payment
Contact information
For more details, pls contact us freely.
Contact name: Tina
Email address: Tina@fdachem.com
Mob: 86 13213167925
WhatsApp/Skype/Wechat/LINE: 86 15225627621
Company Profile Introduction
You may like
![butylidenebis[2-tert-butyl-5-methyl-p-phenylene]-P,P,P',P'-tetratridecylbis(phosphine)](https://img.chemicalbook.com/ProductImageEN1/2025-09/Large/221bba55-a7da-44d7-8d5f-589b9f560bd9.png)
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $48.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-04-20 | |
|
VIP4Y
|
Henan Aochuang Chemical Co.,Ltd.
|
2025-04-04 | ||
| $27.00 |
Shanghai Getian Industrial Co., LTD
|
2024-05-15 | ||
| $7.00 |
VIP7Y
|
Career Henan Chemical Co
|
2020-02-17 |
China