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Postion:Product Catalog >API>Specialty drugs>Antidote>Succimer
Succimer
  • Succimer

Succimer NEW

Price Get Latest Price
Package 1KG 25KG
Min. Order: 1KG
Supply Ability: 1000kg
Update Time: 2026-06-03

Product Details

Product Name: Succimer CAS No.: 304-55-2
EC-No.: 206-155-2 Min. Order: 1KG
Purity: 99% Supply Ability: 1000kg
Release date: 2026/06/03

Succimer (chemically known as meso-2,3-dimercaptosuccinic acid or DMSA) is primarily used as a chelating agent in clinical medicine, specifically for treating heavy metal poisoning. Its applications are highly specialized and revolve around its ability to bind toxic metals for safe excretion. Here's a detailed breakdown:

1. Primary Application: Treatment of Lead Poisoning

  • Mechanism:
    Succimer's two sulfhydryl (–SH) groups form stable, water-soluble complexes with lead (Pb2?), facilitating renal excretion.

  • Key Advantages:

    • Oral Administration: Unlike older agents (e.g., EDTA, which requires IV infusion), Succimer is given orally.

    • Targeted Chelation: Binds lead more selectively than calcium or zinc, reducing essential mineral depletion.

    • Lower Toxicity: Safer than dimercaprol (BAL), especially in children.

  • Use Cases:

    • Children with Blood Lead Levels (BLL) ≥ 45 μg/dL: First-line treatment per CDC guidelines.

    • Adults with Symptomatic Lead Poisoning or High BLL.

    • Asymptomatic Patients with extremely elevated BLL (e.g., >70 μg/dL).


2. Secondary Applications: Other Heavy Metal Poisonings

  • Mercury (Hg) Poisoning:
    Effective for elemental and inorganic mercury exposure (e.g., industrial spills).
    Less effective for methylmercury (found in fish).

  • Arsenic (As) Poisoning:
    Used as an alternative to dimercaprol (BAL) for acute/chronic arsenic toxicity.

  • Cadmium (Cd) & Antimony (Sb):
    Limited evidence, but may be considered if standard therapies fail.


3. Diagnostic Use: Lead Mobilization Test

  • Measures urinary lead excretion after a Succimer dose to confirm lead burden in ambiguous cases.


4. Research & Investigational Uses

  • Neuroprotection: Studied for mitigating lead-induced neurotoxicity (e.g., in developmental delays).

  • Antioxidant Effects: May reduce oxidative stress from metal toxicity.

  • Autism Spectrum Disorders (ASD):
    Controversial and not evidence-based – sometimes misused for "chelation therapy" in ASD without proven benefit. Not recommended due to risks.


Company Profile Introduction

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber.

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