Synucleozid NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: Synucleozid | CAS No.: 502139-01-7 |
| Supply Ability: 10g | Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | Synucleozid |
| Description | Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson's disease. |
| In vitro | Synucleozid (0.25-1 μM; 24 hours) eliminates α-synuclein preformed fibrils induced cytotoxicity by acting as seeds and recruiting endogenous α-synuclein aggregation. It binds to the A bulge near the base of the IRE hairpin, reducing α-synuclein levels in a dose-dependent manner (IC50: 500 nM), and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells. Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities, decreasing 2-AP emission (EC50: 2.7 μM), with recovery observed as a function of unlabeled SNCA IRE RNA concentration, yielding a competitive Kd of 1.5 μM. Additionally, Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins with IREs in their mRNA's UTR, such as APP, PrP, Ferritin, and TfR, in a dose-dependent manner. All panels are completed in SH-SY5Y cells, except for PrP protein, which is assessed in Neuro-2A cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Synucleozid | SNCA IRE RNA | NSC-377363 | NSC377363 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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