一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Inhibitors>Stem Cells & Wnt>Hedgehog / Smoothened inhibitor>Taladegib
Taladegib
  • Taladegib

Taladegib NEW

Price $56 $87 $151
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: Taladegib CAS No.: 1258861-20-9
Purity: 99.80% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameTaladegib
DescriptionTaladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity.
In vitroLY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. [1]
In vivoTaladegib has excellent pharmacokinetic properties in rodent and non-rodent species. Taladegib administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. Taladegib reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and Taladegib induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. Taladegib inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. [2]
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 5.64 mg/mL (11 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.95 mM), Sonication is recommended.
KeywordsTaladegib | Smoothened | Smo | LY-2940680 | LY 2940680 | Inhibitor | inhibit | Hedgehog
Inhibitors RelatedItraconazole | Naftifine hydrochloride | IHR-1 | GANT 61 | ALLO-2 | 5-LOX inhibitor | Ellagic acid | Triparanol | Vismodegib | Halcinonide | MRT-83 | RU-SKI 43
Related Compound LibrariesFailed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | GPCR Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$1.00
VIP7Y
Career Henan Chemical Co
2019-12-20

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY
抚松县| 芮城县| 株洲县| 廉江市| 合江县| 广河县| 公主岭市| 鞍山市| 额敏县| 扶风县| 那曲县| 武隆县| 怀远县| 西安市| 安陆市| 和静县| 呼图壁县| 普兰县| 阜新市| 永丰县| 育儿| 茌平县| 商水县| 清流县| 高陵县| 华坪县| 稷山县| 乌鲁木齐县| 湄潭县| 华蓥市| 徐闻县| 通化县| 景东| 岗巴县| 平度市| 伊春市| 油尖旺区| 辉南县| 武冈市| 锡林浩特市| 庄河市|