Tandospirone NEW
| Price | $30 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-12 |
Product Details
| Product Name: Tandospirone | CAS No.: 87760-53-0 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2026/05/12 |
Product Introduction
Bioactivity
| Name | Tandospirone |
| Description | Tandospirone (SM-3997) is a selective and potent 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity that potentiates the anticardiac fibrotic effect of valsartan in spontaneously hypertensive rats, and can be used in the study of central nervous system disorders. |
| In vitro | Tandospirone has negligible effects at 5-HT1B receptors, 5-HT uptake sites, β-adrenergic receptors, muscarinic cholinergic receptors, and benzodiazepine receptors. [1]3H-Tandospirone rapidly binds to rat brain hippocampal membranes and achieves binding in a high-affinity, reversible, and saturating fashion (Kd: 9.4 nM, Bmax: 213 fmol/mg protein). [2] |
| In vivo | Chronic administration of Tandospirone (0.2 and 1.0 mg/kg/day, but not 2.0 mg/kg/day) was effective in alleviating elevated levels of eLAC in the anterior cingulate cortex (mPFC) due to foot shock stress. [3] After acute administration of Tandospirone (0, 0.1 and 1 mg/kg, intraperitoneally) to rats, a significant reduction in the number of premature responses in a dose-dependent manner was observed, an index used to assess impulsive behavior. [4] |
| Storage | Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble) DMSO : 15 mg/mL (39.11 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.22 mM), Sonication is recommended. |
| Keywords | Tandospirone | SM 3997 | 5HTReceptor | 5-HT1A | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | Dopamine hydrochloride | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Approved Drug Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Toxic Compound Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | NMPA-Approved Drug Library | Serotonin Receptor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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