TCS 2002 NEW
| Price | $3850 |
| Package | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-01-05 |
Product Details
| Product Name: TCS 2002 | CAS No.: 1005201-24-0 |
| Supply Ability: 10g | Release date: 2026/01/05 |
Product Introduction
Bioactivity
| Name | TCS 2002 |
| Description | GSK-3β inhibitor 9 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC 50 of 35 nM. GSK-3β inhibitor 9 exhibits good pharmacokinetic profiles including favorable BBB penetration. GSK-3β inhibitor 9 is able to be used for the research of Alzheimer's disease [1]. |
| In vivo | GSK-3β inhibitor 9 (Compound 9b) exhibited potent pharmacokinetic properties when administered to GS rats and C57BL/6N mice at doses ranging from 1-3 mg/kg over periods of 1-24 hours. It demonstrated favorable blood-brain barrier (BBB) permeability, indicated by an AUC (area under the curve) 0-24h value of 734 ng?h/g and a brain-to-plasma ratio (Kp value) of 1.6. In experiments utilizing 8-week-old male IGS rats, Compound 9b was administered intravenously and orally at dosages of 1 and 3 mg/kg across various time points (1, 2, 4, 8, 24 hours). This treatment resulted in a volume of distribution (Vdss,iv) ranging from 1134 to 1650 mL/kg, total clearance (CLtotal,iv) between 27.4 and 28.4 mL/min/kg, and a maximum concentration (Cmax,po) from 289.6 to 396.9 ng/mL. Additionally, oral administration led to AUC 0-24 h values between 1229.1 and 1380.6 ng?h/mL, mean residence time (MRTpo) from 2.19 to 3.03 hours, and fraction dosed (Fd%) from 65.5 to 72.8%. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | TCS-2002 | TCS2002 | TCS 2002 |
| Inhibitors Related | Cromolyn sodium | 4-Methyl-6-Methoxycoumarin | Indazole | GSK 3 Inhibitor IX | AT7519 | 5-Bromoindole | 4-Chloro-2'-bromoacetophenone | SNS-032 | Ethyl linoleate | Ginsenoside Rg2 | GSK-3 Inhibitor 5 | ROCK-IN-5 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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