MYF-03-69 NEW
| Price | $893 | $1160 | $1860 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: MYF-03-69 | CAS No.: 2416418-11-4 |
| Supply Ability: 10g | Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | MYF-03-69 |
| Description | MYF-03-69 (TEAD-IN-3) is a covalent and irreversible pan-TEAD inhibitor with IC?? values of 385/143/558/173 nM for TEAD1/TEAD2/TEAD3/TEAD4, respectively. MYF-03-69 inhibits TEAD transcriptional activity (IC?? = 56 nM), upregulates the pro-apoptotic gene BMF, and suppresses mesothelioma cancer cells with defective Hippo signaling, making it suitable for malignant pleural mesothelioma (MPM). |
| In vitro | MYF-03-69 (0–10 μM; 5 days) selectively inhibits proliferation of mesothelioma cells with defective Hippo signaling (e.g., NCI-H226, MSTO-211H) with impaired Hippo signaling, while exhibiting minimal cytotoxicity toward normal mesothelial cells or cancer cells with intact Hippo signaling [1]. MYF-03-69 (0.1–10 μM; 48 h) induced G1 phase cell cycle arrest in NCI-H226 and MSTO-211H cells [1]. MYF-03-69 (2 μM) inhibits TEAD protein palmitoylation, downregulates YAP-TEAD target genes (e.g., CTGF, CYR61, ANKRD1) in NCI-H226 cells, and upregulates the pro-apoptotic gene BMF [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (180.42 mM), Sonication is recommended. |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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