Product Details
| Product Name: Tegoprazan | CAS No.: 942195-55-3 |
| Min. Order: 1kg | Purity: 99% |
| Supply Ability: 100kg | Release date: 2026/04/17 |
| Lead time: in stock | Packaging: bag/bottle/drum//IBC, as request |
| Delivery: By sea, by air, by express | Origin: Manufacturer, advantage products |
| COA, MSDS: Available, contact us for details | Contact: Tina |
PRODUCT INFORMATION
| Common Name | Tegoprazan | ||
|---|---|---|---|
| CAS Number | 942195-55-3 | Molecular Weight | 387.38 |
| Density | N/A | Boiling Point | N/A |
| Molecular Formula | C20H19F2N3O3 | Melting Point | N/A |
| MSDS | N/A | Flash Point | N/A |
| Purity | Quantity | Budget | Inquiry |
|---|
Use of TegoprazanTegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro[1]. |
| Name | Tegoprazan |
|---|
| Description | Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro[1]. |
|---|---|
| Related Catalog | Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Metabolic Disease |
| Target | IC50: 0.29-0.52 μM (H+/K+-ATPase)[1]. |
| In Vitro | Tegoprazan inhibits porcine, canine, and human H+/K+-ATPase activity. Tegoprazan inhibits gastric H+/K+-ATPase in a potassium-competitive and reversible manner. Tegoprazan (3 μM) inhibits 86% of H+/K+-ATPase activity, whereas the inhibition is decreased to 34% after the dilution of Tegoprazan concentration to 0.15 μM[1]. |
| In Vivo | Tegoprazan (1.0 mg/kg, p.o.) potently and completely inhibits histamine-induced gastric acid secretion in dogs. Tegoprazan (1.0-3.0 mg/kg, p.o.) reverses the pentagastrin-induced acidified gastric pH to the neutral range. Tegoprazan (3 mg/kg, p.o.) immediately evokes a gastric phase III contraction of the migrating motor complex in pentagastrin-treated dogs[1]. |
| References | [1]. Takahashi N, et al. Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility. J Pharmacol Exp Ther. 2018 Feb;364(2):275-286. |
| Molecular Formula | C20H19F2N3O3 |
|---|---|
| Molecular Weight | 387.38 |
| Storage condition | -20°C |
Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
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Our products have been exported to many countries, including Germany, Spain, the United Kingdom, the United States, Australia, the Middle East, Asia, and more. We have received highly positive feedback from our clients and have established long-term friendly cooperative relationships with them.
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Excellent quality is one of the cornerstones of our success. We welcome ordering samples for quality testing.
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1kg/bag, 25kg/drum, 50kg/drum, 180kg/drum, 200kg/drum, 1T/bag/drum, standard export packaging or packaging required by customers
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Contact name: Tina
Email address: Tina@fdachem.com
Mob: 86 13213167925
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Company Profile Introduction
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