TGFβ1-IN-3 NEW
| Price | $82 | $203 | $291 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-06 |
Product Details
| Product Name: TGFβ1-IN-3 | CAS No.: 2883813-58-7 |
| Purity: 99.73% | Supply Ability: 10g |
| Release date: 2026/05/06 |
Product Introduction
Bioactivity
| Name | TGFβ1-IN-3 |
| Description | TGFβ1-IN-3, a diarylhydrazone derivative, inhibits fibroblast activation and proliferation, positioning it as a candidate compound for the treatment of idiopathic pulmonary fibrosis (IPF). |
| In vitro | TGFβ1-IN-3 (compound 44) inhibits NIH-3T3 cells with an IC50 of 0.57 μM. At 10 μM for 24 hours, it inhibits TGF-β1-induced abnormal activation of NIH-3T3 and A549 cells, as well as migration and epithelial-mesenchymal transition (EMT) of A549 cells. TGFβ1-IN-3 binds to STAT3, interacting with Ile659, while the hydrophilic piperidine forms intermolecular forces with Ser636, Arg609, and Pro639. The nitrofuran of TGFβ1-IN-3 interacts with Lys658.[1] |
| In vivo | TGFβ1-IN-3 (compound 44) administered orally at 30-60 mg/kg once daily for 22 days in C57BL/6 mice slows IPF progression and enhances lung function, potentially reversing pulmonary fibrosis in a treatment model.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45 mg/mL (101.69 mM), Sonication is recommended. |
| Inhibitors Related | Trimethylamine N-oxide | Melamine | SB-431542 | Hydrochlorothiazide | Hippuric acid | Chromenone 1 | Pirfenidone | A 83-01 | Suberic acid | Cetrimonium bromide | Galunisertib | Alantolactone |
| Related Compound Libraries | Bioactive Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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