Theophylline is an alkaloid derived from tea and coffee and belongs to the purine family of alkaloids. purines are widely distributed in the plant kingdom, and more in higher plants, especially in theaceae and rubiaceae. Theophylline is an active component of the tea Camelliasinensis in the camelliasinensis family. Theophylline can now be synthesized. Theophylline monohydrate is monoclinic flat flake crystal (water), the commercially available product is white crystalline powder, 1g can be dissolved in 120mL water, 80mL ethanol and 110mL chloroform; Soluble in hot water, sodium hydroxide, ammonia, olefinic acid or nitric acid; Slightly soluble in ether. The characteristic wavelength of UV absorption (molar absorption coefficient) is 270nm. Although theophylline exists in tea, it has little oral safety. The oral LD50 of rabbits is 0.30 ~ 0.49mg/kg, and no unsafe reports have been reported for external use. Theophylline is a commonly used drug to treat angina pectoris, which can relax smooth muscle when applied externally. Theophylline can also improve the activity of melanocytes and accelerate the formation of melanin. Copper gluconate is a synergist of theophylline. Theophylline can be used in hair water to prevent the formation of gray hair, and the combination of long chain fatty acids or alcohols with odd carbon atoms is better. Theophylline has anti-inflammatory properties and is used with an aqueous glycerin extract from seaweed to treat cellulitis.