Thiabendazole NEW
| Price | $29 |
| Package | 1g |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Thiabendazole | CAS No.: 148-79-8 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Thiabendazole |
| Description | Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property. |
| In vitro | Thiabendazole provokes a strong DNA-damaging activity in the human lymphoblastoid cell line that constitutively expresses human CYP1A1 cDNA, but not in the parental line, indicating that CYP1A1 is chiefly implicated in carbaryl and thiabendazole genotoxicity. [1] Thiabendazole provokes a dose- and time-dependent increase in CYP1A1 (EROD activity, protein and mRNA levels) in primary culture of rat hepatocytes. [2] Thiabendazole results in the induction of 7-ethoxyresorufin O-deethylase and 7-pentoxyresorufin O-depentylase activities, CYP1A1, CYP1A2, CYP2B1 and CYP2B1/2 mRNA levels and CYP1A2 and CYP2B1/2 apoprotein levels. Thiabendazole markedly induces GSTP1 mRNA levels, but has only a small effect on GSTT1 mRNA levels. [3] Thiabendazole is rapidly transported by passive diffusion through the human intestinal cells by comparison with the protein-bound residues which are not able to cross the intestinal barrier. Thiabendazole will be firstly metabolized to 5OH-TBZ and subsequently converted to a chemically reactive metabolic intermediate binding to proteins. [4] |
| In vivo | Thiabendazole results in nephrosis or hydronephrosis and this organ toxicity may lead to the high dose-dependent mortality in treated mice. Thiabendazole results in hormone imbalance and this imbalance may play an important role in the changes of the reproductive or endocrine system in treated mice. [5] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 5 mg/mL (24.84 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+90% Corn oil : 5 mg/mL (24.84 mM), Solution. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 1 mg/mL (4.97 mM), Sonication is recommended. DMSO : 50 mg/mL (248.45 mM), Sonication is recommended. 10% DMSO+90% (20% SBE-β-CD in Saline) : < 5 mg/mL (24.84 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 5 mg/mL (24.84 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| Keywords | Tubulin β | Thiabendazole | Parasite | MitochondrialMetabolism | Mitochondrial Metabolism | MicrotubuleAssociated | Microtubule Associated | Inhibitor | inhibit |
| Inhibitors Related | Kaolin | Imeglimin hydrochloride | 2-Chloropyrazine | D(+)-Raffinose pentahydrate | Hydroxychloroquine | Metronidazole | Hydroxypropyl Cellulose | 2-Amino-2-methyl-1-propanol | Doxycycline | Fenpyroximate | Gluconate Calcium | Sodium Molybdate |
| Related Compound Libraries | Pesticide Compound Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Fungal Compound Library | Drug Repurposing Compound Library | Tobacco Monomer Library | FDA-Approved Drug Library | FDA-Approved Kinase Inhibitor Library | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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