Ticagrelor NEW
| Price | $40 | $60 | $73 |
| Package | 10mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Ticagrelor | CAS No.: 274693-27-5 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Ticagrelor |
| Description | Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The drug was approved for use in the European Union by the European Commission on December 3, 2010, and by the US FDA on July 20, 2011. Its trade names are Brilinta (US), Brilique(EU) and Possia(EU). |
| In vitro | Ticagrelor has a half-life (t1/2) of approximately 7-8.5 hours and exhibits a dose-related inhibition of platelet aggregation; a 100-400 mg dose achieves complete inhibition within 2 hours. It is well-tolerated, with no serious adverse events or significant changes in laboratory values observed. Ticagrelor is rapidly absorbed, reaching peak levels in 1.3-2 hours. Within the studied dosage range, both the peak concentration of Ticagrelor and the area under the curve (from time zero to infinity) increase in a dose-proportional manner, indicating linear pharmacokinetics. |
| In vivo | In binding studies on CHO-K1 cells transfected with rh-P2Y12 receptors, Ticagrelor exhibited efficient and reversible binding, with a kon (association rate constant) of 0.00011/(nM·s), a Kd (equilibrium dissociation constant) of 10.5 nM, and a koff (dissociation rate constant) of 0.00087/s. The half-lives for association and dissociation were 4 and 14 minutes, respectively, suggesting that the concentration of the drug that binds to platelets determines the extent of platelet inhibition. Ticagrelor is an active drug that does not require metabolic activation. It does not directly compete with ADP at the ADP binding site but rather occupies a nearby site, causing a change in the conformation of the binding site that leads to a reversible conformational change in the receptor. The binding of Ticagrelor to the receptor is reversible with quick onset/off rates. |
| Storage | Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (478.4 mM), Sonication is recommended. 5% DMSO+40 % PEG300+5 % Tween 80+50 % Saline : 5 mg/mL (9.57 mM), Solution. 10% DMSO+90% Saline : < 10 mg/mL (19.14 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (19.14 mM), Solution. |
| Keywords | Ticagrelor | P2YReceptor | P2Y12 | P2Y Receptor | P2Y | Inhibitor | inhibit | CYP2C9 | AZD-6140 | AZD 6140 |
| Inhibitors Related | Tebuconazole | Oxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Sudan IV | Naringin | Tauroursodeoxycholate | Dibenzothiophene | Clarithromycin | Memantine hydrochloride |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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