Tinidazole NEW
| Price | $42 |
| Package | 500mg |
| Supply Ability: | 10g |
| Update Time: | 2025-05-07 |
Product Details
| Product Name: Tinidazole | CAS No.: 19387-91-8 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2025/05/07 |
Product Introduction
Bioactivity
| Name | Tinidazole |
| Description | Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death. |
| In vivo | Tinidazole exhibits antimicrobial activity against a broad range of bacteria, including notable anaerobic species (e.g., Bacteroides fragilis, Clostridium difficile), pathogenic protozoa (e.g., Trichomonas vaginalis, Entamoeba histolytica, Giardia duodenalis), and microaerophilic Helicobacter pylori. The compound is active against clinical isolates of 10 Prevotella bivia strains, 11 Bacteroides fragilis strains, and 40 Clostridium difficile strains. The average minimum inhibitory concentrations (MIC) for Tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL. In susceptible bacterial and protozoal cells, Tinidazole is reduced to a cytotoxic intermediate that covalently binds to DNA, causing irreversible damage. At low minimum lethal concentrations (MLC), Tinidazole can kill metronidazole-sensitive strains but is only effective against 4 out of 12 metronidazole-resistant strains. Additionally, Tinidazole inhibits all 104 T. vaginalis strains tested with an average MLC of 1014.9 μM and alters morphology, viability, and compliance of trophozoites to Giardia duodenalis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (242.65 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | Tinidazole | Inhibitor | inhibit | infections | CP-12574 | CP 12574 | Bacterial | bacteria | antimicrobial | Antibiotic | anaerobic |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Doxycycline | EDTA copper(II) disodium salt | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Pediatric Drug Library | Drug-induced Liver Injury (DILI) Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | CNS-Penetrant Compound Library | Anti-Bacterial Compound Library | FDA-Approved Drug Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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