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Postion:Product Catalog >Tisolagiline
Tisolagiline
  • Tisolagiline

Tisolagiline NEW

Price Get Latest Price
Package 1removed
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: Tisolagiline CAS No.: 1894207-44-3
Supply Ability: 10g Release date: 2026/06/02

Product Introduction

Bioactivity

NameTisolagiline
DescriptionTisolagiline (KDS2010) is a potent, highly selective and reversible MAO-B inhibitor with IC50=8 nM and oral activity for the treatment of Alzheimer's disease and obesity.
In vitroTisolagiline demonstrated high potency in inhibiting MAO-B in human cell assays, with an IC?? of 8.0 nM, showing over 1,250-fold selectivity for MAO-B over MAO-A[1].
In vivoIn a MPTP-induced Parkinson’s disease mouse model, oral administration of Tisolagiline (10 mg/kg/day for 5 days) significantly protected dopaminergic neurons in the substantia nigra and improved motor function. Furthermore, chronic administration in non-human primates (cynomolgus monkeys) showed favorable pharmacokinetics and safety at doses up to 100 mg/kg/day for 4 weeks, with reversible MAO-B inhibition and no significant adverse effects observed[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.
Solubility Information10% DMSO+90% Saline : < 10 mg/mL (31.02 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
10% DMSO+90% Corn Oil : 3.3 mg/mL (10.24 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (31.02 mM), Solution.
DMSO : 125 mg/mL (387.8 mM), Sonication is recommended.
KeywordsTisolagiline | MonoamineOxidase | Monoamine Oxidase | KDS-2010
Inhibitors RelatedSafinamide | 1,4-Naphthoquinone | 4-Chlorochalcone | Paeonol | Hydroxylamine hydrochloride | Isatin | Methylene Blue trihydrate | β-Aminopropionitrile | Aminoacetone hydrochloride | Allylthiourea | D-(-)-Quinic acid | Amitraz
Related Compound LibrariesAnti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

Product name Price   Suppliers Update time
Anhui Ruihan Technology Co., Ltd
2023-08-21

TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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