Product Details
| Product Name:
TMC353121 |
CAS No.:
857066-90-1 |
| Purity:
≥98% |
Supply Ability:
10g |
| Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | TMC353121 |
| Description | TMC353121 is a respiratory syncytial virus (RSV) fusion inhibitor with anti-RSV activity that inhibits the production of the inflammatory cytokines TNF-α, IL-6, and IL-1β, as well as chemokines, KC, IP-10, MCP, and MIP1-α. |
| In vitro | TMC353121 is an effective RSV fusion inhibitor, active against wild-type RSV (strain LO) with a 50% effective concentration (EC50) of 0.07 ng/mL in HeLaM cells[2]. |
| In vivo | After single subcutaneous administration and repeated administration 24 hours post-intranasal RSV inoculation, TMC353121 dose-dependently reduces viral titers in bronchoalveolar lavage fluid[2]. |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.58 mM), Sonication is recommended. DMSO : 30 mg/mL (53.7 mM), Sonication is recommended.
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| Keywords | TNF-α | TMC-353121 | TMC353121 | TMC 353121 | RSV | ILReceptor | IL-6 | IL Receptor |
| Inhibitors Related | Kaolin | Fluorene | Undecane | Acetylcysteine | Gum arabic | Triphenyl phosphate | 1,8-Cineole | Dodecane | Tributyrin | Glucosamine | Diallyl disulfide | Perflubron |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |