TML-6 NEW
| Price | $787 | $1180 | $1860 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: TML-6 | CAS No.: 1462868-88-7 |
| Purity: 99.71% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | TML-6 |
| Description | TML-6 is an orally available curcumin derivative that inhibits synthesis of β-amyloid (Aβ) and Aβ precursor protein, upregulates Apo E, activates Nrf2, suppresses NF-κB and mTOR, and ameliorates inflammation. It is suitable for Alzheimer's disease research. |
| In vitro | TML-6 exhibits no toxicity to Huh-7 cells at concentrations below 5 μM, with an IC50 value of 4.19 μg/mL. TML-6 significantly activates the Nrf2 gene at a concentration of 1.32 μg/mL [1]. |
| In vivo | TML-6 (dietary, 150 mg/kg/day for four months) improved Aβ levels and Iba-1 expression in the brains of 3xTg (mutations: APPKM670/671NL, MAPTP301L, and PSEN1M146V) AD transgenic mice, significantly reducing their learning behavior [1]. After oral administration of 150 mg/kg TML-6 in SD rats, the plasma concentration of TML-6 reached a peak C-max of 35.9±15.6 ng/mL, with a T-max of 3.67±2.08 hours [1]. |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 95 mg/mL (181.43 mM), Sonication is recommended. |
| Keywords | TML-6 | TML 6 |
| Inhibitors Related | Aceglutamide | Sodium propionate | Kojic acid | HEPPS | Fumaric acid | 1,4-Naphthoquinone | Curcumin | Ethyl linoleate | D-Psicose | L-Methionine | L-Cystine | N,N-Dimethylacetamide |
| Related Compound Libraries | PI3K-AKT-mTOR Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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