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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Epigenetics>HDAC inhibitors>TMP269
TMP269
  • TMP269

TMP269 NEW

Price $55 $89 $139
Package 2mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: TMP269 CAS No.: 1314890-29-3
Purity: 99.72% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameTMP269
DescriptionTMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.
Cell ResearchHuman CD4+ T cells are isolated from whole blood via negative selection according to manufacturer's instructions (RosetteSep Human CD4+ T cell enrichment kit), re-suspended in T-cell culture medium (10% FBS, 2 mM L-glutamine, 1 mM pyruvate, 10 mM HEPES, 10 U/10 mg penicillin/streptomycin, 0.5% DMSO in RPMI) and plated at 50,000 cells/well with IL-2 (10 BRMP units/mL) and 100,000 human T-expander Dynabeads for 72 h. Determination of mitochondrial function or cell viability is done according to manufacturer's instructions (Cell Proliferation Assay Kit I (MTT)) and is represented as a percent of control (no inhibitor) wells.(Only for Reference)
Kinase AssayHDAC selectivity assays: Dose-response studies are done with ten concentrations in a threefold dilution series from a maximum final compound concentration of 100 μM in the reaction mixture and are conducted at Reaction Biology Corp. All assays are based on the same principle as the HDAC9 assay described above: the deacetylation of acetylated or trifluoroacetylated lysine residues on fluorogenic peptide substrates by HDAC. HDAC1, HDAC2, HDAC3, HDAC6, HDAC10 and HDAC11 used a substrate based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)). For HDAC8, the diacetylated peptide substrate, based on residues 379–382 of p53 (Arg-His-Lys(Ac)-Lys(Ac)), is used. HDAC4, HDAC5, HDAC7 and HDAC9 assays used the class IIa HDAC–specific fluorogenic substrate (Boc-Lys(trifluoroacetyl)-AMC). All reactions are done with 50 μM HDAC substrate in assay buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, 1 mg/mL BSA) containing 1% DMSO final concentration; incubated for 2 h at 30 °C; and developed with trichostatin A and trypsin.
In vivoTMP269 (10 μM) does not affect mitochondrial activity and/or the activity of human CD4+ T cells and can be used to identify endogenous substrates of class IIa HDAC enzymes. In IEC-18 small intestinal epithelial cells, TMP269 inhibits cellular processes, DNA synthesis, and proliferation induced by the activation of G protein-coupled receptor/PKD1 signaling.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 225 mg/mL (437.3 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 10 mg/mL (19.44 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
Ethanol : 2 mg/mL (3.89 mM), Heating is recommended.
10% DMSO+90% Corn oil : 10 mg/mL (19.44 mM), Solution.
10% DMSO+90% Saline : < 10 mg/mL (19.44 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+90% (20% SBE-β-CD in Saline) : < 10 mg/mL (19.44 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
KeywordsTMP-269 | TMP269 | TMP 269 | Inhibitor | inhibit | Histone deacetylases | HDAC9 | HDAC7 | HDAC5 | HDAC4 | HDAC
Inhibitors RelatedPanobinostat | Theophylline monohydrate | Valproic acid sodium salt | Methoxyacetic acid | Sodium 4-phenylbutyrate | Acefylline | Manganese chloride (tetrahydrate) | Curcumin | Valproic Acid | Sodium butanoate | 4-Phenylbutyric acid | Theophylline
Related Compound LibrariesDNA Damage & Repair Compound Library | Reprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Endoplasmic Reticulum Stress Compound Library | HIF-1 Signaling Pathway Compound Library | Epigenetics Compound Library | Chromatin Modification Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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