TNG-462 NEW
| Price | $283 | $959 |
| Package | 5mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-10 |
Product Details
| Product Name: TNG-462 | CAS No.: 2760483-96-1 |
| Purity: 99.59% | Supply Ability: 10g |
| Release date: 2026/07/10 |
Product Introduction
Bioactivity
| Name | TNG-462 |
| Description | TNG-462 is a potent and selective PRMT5 inhibitor with antitumor activity and oral activity, primarily for the treatment of methylthioadenosine phosphorylase (MTAP)-deficient and/or methylthioadenosine (MTA)-accumulating cancers (e.g., non-small-cell lung cancer, pancreatic cancer, bladder cancer, and hematologic malignancies). |
| In vitro | Methods: Tumor cells (NSCLC, PDAC, bladder, hematological malignancies) deficient in MTAP were treated with TNG-462 (0-1 μM) and cell viability was measured. Results: TNG-462 selectively inhibited cell viability with an IC50 value of less than 1 μM. [2] |
| In vivo | Methods: TNG-462 (40 mg twice a day; 100 mg/kg twice a day, orally, for 21 days) was used to treat a xenograft mouse model derived from a MTAP-deficient cell line and observe tumor growth in vivo. Results: TNG-462 inhibited tumor growth in mice and showed anti-tumor activity. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (153.64 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (19.21 mM), Solution. 10% DMSO+90% Saline : < 10 mg/mL (19.21 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| Keywords | HistoneMethyltransferase | Histone Methyltransferase |
| Inhibitors Related | MAK-683 hydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | （Iso）-Flavokawain A | EPZ015666 | iso-Azalansta | AMI-1 free acid | MS37452 | MRTX-1719 | Revumenib |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Post-Translational Modification Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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TargetMol Chemicals Inc.
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2026-04-21 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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