trans-Ned 19 NEW
| Price | $522 | $868 |
| Package | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-25 |
Product Details
| Product Name: trans-Ned 19 | CAS No.: 1354235-96-3 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2026/05/25 |
Product Introduction
Bioactivity
| Name | trans-Ned 19 |
| Description | trans-Ned 19?is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist and two-pore channel (TPC) blocker. It binds with high affinity to the NAADP receptor to inhibit NAADP-dependent lysosomal/endolysosomal calcium release without affecting IP3 or cADPR-mediated calcium signaling pathways. Functionally, trans-Ned 19 inhibits glucose-induced calcium oscillations in pancreatic islets and low histamine concentration-induced endothelium-dependent vasodilation, and reduces Ebola virus infection of host cells. In immunomodulation, NAADP signaling blockade by trans-Ned 19 promotes the conversion of mouse Th17 cells to regulatory T cells (Tregs) and shows protective effects in intestinal inflammation models. |
| In vitro | trans-Ned 19 (25–100 μM; 1 h) inhibits T-cell receptor (TCR)-stimulated Ca2? signaling, cell activation, and proliferation in primary immature CD4? T cells from C57BL/6N mice [1]. trans-Ned 19 (25–50 μM; 10 min) inhibits norepinephrine (HY-13715)-induced Ca2? elevation in rat aortic smooth muscle cells in a concentration-dependent manner [2]. trans-Ned 19 (100 μM; 30 min) significantly increased the rate of spontaneous acrosome reaction in the acrosome reaction assay of permeabilized mouse sperm [3]. |
| In vivo | trans-Ned 19 (20 mg/kg; intraperitoneal injection; administered once 2 hours prior to the first injection of anti-CD3 mAb, followed by a second dose 48 hours later) reduced disease severity in a mouse model of anti-CD3 mAb-induced intestinal inflammation, as evidenced by reduced weight loss [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (155.46 mM), Sonication is recommended. |
| Keywords | trans-Ned 19 | transNed 19 | trans Ned 19 | CalciumChannel | Calcium Channel | Ca2+ |
| Inhibitors Related | Quadrol | Nisoldipine | Tricaine methanesulfonate | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Nifedipine | Magnesium Chloride Hexahydrate | Magnesium sulfate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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