Product Details
| Product Name:
UCB-9260 |
CAS No.:
1515888-53-5 |
| Purity:
99.24% |
Supply Ability:
10g |
| Release date:
2026/06/10 |
Product Introduction
Bioactivity
| Name | UCB-9260 |
| Description | UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer. |
| In vitro | In Hek-293 cells, UCB-9260 (0-10 μM)?inhibits NF-κB with a geometric mean IC50?of 202?nM after TNF (10?pM) stimulation. UCB-9260?inhibits TNF-dependent cytotoxicity with a geometric mean IC50?of 116?nM and a geometric mean IC50?of 120?nM, using human and mouse TNF, respectively. |
| In vivo | UCB-9260 (150?mg/kg; p.o.) treatment twice daily?for 7 days shows a significant reduction of the clinical score. In adult male Balb/c mice, UCB-9260?(10-300?mg/kg; p.o.) dose-dependently inhibits human and mouse TNF-induced neutrophil recruitment to the peritoneal compartment. |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 81.7 mg/mL (192.91 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (11.81 mM), Sonication is recommended.
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| Keywords | UCB-9260 | UCB9260 | UCB 9260 | Tumor Necrosis Factor Receptor | trimer | TNFR | TNF Receptor | TNF | selective | rheumatoid | neutrophil | Inhibitor | inhibit | cytotoxicity | cytokine | autoimmune | asymmetric | arthritis |
| Inhibitors Related | Kaolin | Fluorene | Undecane | Ethyl palmitate | Acetylcysteine | Gum arabic | 1,8-Cineole | Dodecane | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Apremilast |
| Related Compound Libraries | Apoptosis Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Inhibitor Library | NO PAINS Compound Library | Immuno-Oncology Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1520.00
|
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-04-21 |
|
|
$98.00
|
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-06-10 |
United States