UK-101 NEW
| Price | $239 | $446 | $718 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: UK-101 | CAS No.: 1000313-40-5 |
| Purity: 99.25% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | UK-101 |
| Description | UK-101 is a small molecule inhibitor and a selective inhibitor of the immunoproteasome β1i (LMP2) subunit (IC50=104 nM), with 144-fold and 10-fold selectivity over the β1c and β5 subunits, respectively. This compound can induce apoptosis, possesses antitumor activity, and can be used for prostate cancer-related research. |
| In vitro | Methods: PC-3 cells were treated with various concentrations of UK-101 (1-8 μM) for 24 hours, and cell cycle distribution, p27 protein accumulation, and PARP cleavage were detected. Results: UK-101 induced cell cycle arrest at the G1 phase, increased the number of cells in the G1 phase, enhanced p27 protein accumulation, and significantly increased PARP cleavage in a dose-dependent manner.[1] |
| In vivo | Methods: To detect the in vivo antitumor activity and toxicity of UK-101, tumor-bearing mice were intraperitoneally injected with UK-101 (1-3 mg/kg, twice weekly for 3 weeks), tumor volume changes were measured, and mouse body weight was monitored. Results: UK-101 treatment reduced tumor volume in a dose-dependent manner, with significant tumor volume reduction at the 3 mg/kg dose; meanwhile, mouse body weight remained stable during the treatment period, indicating low systemic toxicity.[1] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 3.3 mg/mL (6.81 mM), Sonication is recommended. DMSO : 237.5 mg/mL (489.95 mM), Sonication is recommended. |
| Keywords | UK-101 | LMP2 | immunoproteasome β5 | immunoproteasome β1c |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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