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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>UNC0224
UNC0224
  • UNC0224

UNC0224 NEW

Price $31 $64 $106
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: UNC0224 CAS No.: 1197196-48-7
Purity: 99.80% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameUNC0224
DescriptionUNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.
In vitroIn G9a ECSD and CLOT assays, the IC50 values are 43 nM and 57 nM for UNC0224, respectively. In GLP ECSD and CLOT assays, the IC50 values are 50 nM and 58 nM for UNC0224, respectively. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. In ITC experiments, the Kd of UNC0224 to the G9a protein is 23 nM[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+90% Saline : 3.57 mg/mL (7.35 mM), Solution.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.06 mM), Sonication is recommended.
DMSO : 35.71 mg/mL (73.53 mM), Sonication is recommended.
KeywordsUNC-0224 | UNC0224 | UNC 0224 | stabilized | SAR | quinazoline | PKMT | p53 | lysine | K373 | Inhibitor | inhibit | HistoneMethyltransferase | Histone Methyltransferase | H3K9 | GLP | G9a | chromatin
Inhibitors RelatedMAK-683 hydrochloride | SNDX-5613 | Tazemetostat | Piribedil | XY1 | UNC 0631 | (Iso)-Flavokawain A | EPZ015666 | iso-Azalansta | AMI-1 free acid | MS37452 | MRTX-1719
Related Compound LibrariesHistone Modification Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Multi-Target Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | High-Efficiency Gene Editing Small Molecule Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Address: 36 Washington Street, Wellesley Hill, MA
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