Product Details
| Product Name:
UniPR129 |
CAS No.:
1639159-47-9 |
| Supply Ability:
10g |
Release date:
2026/04/28 |
Product Introduction
Bioactivity
| Name | UniPR129 |
| Description | UniPR129 is a highly selective, cell-permeable, competitive Eph/ephrin antagonist belonging to the class of L-tryptophan derivatives of lithocholic acid. UniPR129 inhibits the interaction between EphA2 and ephrin-A1 with an IC?? of 945 nM and a Ki of 345 nM. UniPR129 inhibits angiogenesis in HUVEC cells with an IC?? of 5.2 μM. UniPR129 exhibits antitumor and neuroprotective effects and can be used in research on cancer and neurological diseases. |
| In vitro | Methods: Human umbilical vein endothelial cells (HUVECs) were incubated with 0–50 μM UniPR129 for 1 hour, then seeded onto Matrigel; 15 hours later, the formed multi-lumen structures were counted.
Results: UniPR129 effectively inhibited in vitro angiogenesis, with an IC?? of 6.2 μM.[1] |
| In vivo | Methods: To investigate the antitumor effects of UniPR129, APC min/J mice (C57BL6/J background, male, 5 weeks old) were selected and administered UniPR129 (30 mg/kg) orally starting at 5 weeks of age for 8 weeks.
Results: Treatment with UniPR129 reduced the number of ileal adenomas by 42% and the total number of intestinal adenomas by 29%; adenoma diameter was significantly reduced, and no large or giant adenomas were observed.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1?mg/mL?(insoluble)
DMSO : 26.66 mg/mL (46.22 mM), Sonication is recommended.
|
| Keywords | Uni-PR-129 | Uni-PR129 | UniPR129 | Uni-PR 129 | Uni PR-129 | Uni PR129 | Uni PR 129 |
| Inhibitors Related | NVP-BHG712 | ALW-II-49-7 | ALW-II-41-27 | AWL-II-38.3 | Sitravatinib | 123C4 | Urolithin D | Dasatinib monohydrate | KYL acetate(676657-00-4 free base) | JI-101 | AZ12672857 | Tesevatinib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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