Valecobulin hydrochloride NEW
| Price | $81 | $173 | $273 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Valecobulin hydrochloride | CAS No.: 1240321-53-2 |
| Purity: 99.52% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Valecobulin hydrochloride |
| Description | Valecobulin hydrochloride (CKD-516 hydrochloride) is the valine prodrug and vasoblocker of S516. Valecobulin hydrochloride (CKD-516 hydrochloride) has a potent inhibitory effect on β-tubulin polymerization and has significant anti-tumor activity against solid tumors in mice and humans. |
| In vivo | METHODS: Nude mice carrying human colonic HCT116 and human colonic overexpression of the P-gp transporter HCT15 were treated with Valecobulin hydrochloride (CKD-516 hydrochloride) (5 mg/kg and 10 mg/kg, intraperitoneal injection, Q4D 4). RESULTS The IR of Valecobulin hydrochloride (CKD-516 hydrochloride) in HCT116 nude mice was 36% and 65%, respectively, and tumor growth was significantly inhibited in a dose-dependent manner; Valecobulin hydrochloride (CKD-516 hydrochloride) also showed resistance to MDR The potent antitumor activity of positive cell lines (HCT15), with IRs of 12% and 5%, respectively. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 10 mg/mL (17.45 mM), Solution. DMSO : 145 mg/mL (253.03 mM), Sonication is recommended. H2O : 50 mg/mL (87.25 mM), Sonication is recommended. |
| Keywords | β-tubulin polymerization | β-tubulin | VDA | Valecobulin hydrochloride | Valecobulin | S516 | prodrug | MicrotubuleAssociated | Microtubule/Tubulin | Microtubule Associated | Inhibitor | inhibit | CKD-516 Hydrochloride | CKD516 Hydrochloride | CKD-516 | CKD516 | CKD 516 Hydrochloride | CKD 516 | antitumor |
| Inhibitors Related | Flubendazole | N-Phenylbenzylamine | Mebendazole | 4-Isopropoxybenzoic acid | Pregnenolone acetate | Oxfendazole | α-Cyclodextrin | Methylene Blue trihydrate | Paclitaxel | 4'-Demethylepipodophyllotoxin | Albendazole | Colchicine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Microtubule-Targeted Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library | High-Efficiency Gene Editing Small Molecule Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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