VAS2870 NEW
| Price | $52 | $98 | $189 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: VAS2870 | CAS No.: 722456-31-7 |
| Purity: 99.74% | Supply Ability: 10g |
| Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | VAS2870 |
| Description | VAS2870 is an inhibitor of NADPH oxidase (NOX). |
| In vitro | VAS2870 effectively inhibits the growth and proliferation of FaO rat hepatoma cells and various human hepatocellular carcinoma (HCC) cell lines, while also enhancing TGF-b-mediated apoptosis in these cells. It suppresses the activation of NADPH oxidase and the production of intracellular ROS induced by PDGF-BB, without affecting DNA synthesis. Preincubation with VAS2870 at concentrations of 10 and 20 μM completely prevents PDGF-mediated NADPH oxidase activation and ROS production, although it does not interfere with PDGF-induced cell cycle progression. However, VAS2870 does effectively eliminate PDGF-dependent chemotaxis of VSMC, achieving 100% inhibition at 10 μM. Additionally, VAS2870 dose-dependently reduces autocrine cell number increases in FaO rat hepatoma cells, and at 25 mM, it almost completely blocks ROS production and thymidine incorporation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (9.16 mM), Sonication is recommended. DMSO : 83.3 mg/mL (231.14 mM), Sonication is recommended. |
| Keywords | VAS-2870 | VAS2870 | VAS 2870 | NOX | NADPH Oxidase | Inhibitor | inhibit |
| Inhibitors Related | ML171 | Melamine | Metronidazole | Pasiniazid | APX-115 | 2-Methoxy-4-ethylphenol | Dicoumarol | NAD+ | Apocynin | Triclosan | AKR1C1-IN-1 | 6-Aminonicotinamide |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Glutamine Metabolism Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Anti-Cardiovascular Disease Compound Library | NO PAINS Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library | Anti-Metabolism Disease Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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