Verubecestat NEW
| Price | $34 | $55 | $80 |
| Package | 2mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Verubecestat | CAS No.: 1286770-55-5 |
| Purity: 99.55% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Verubecestat |
| Description | Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor. |
| In vitro | Verubecestat(MK-8931) effectively reduces Aβ40 in cells with a Ki of 7.8 nM and an IC50 of 13 nM[2]. |
| In vivo | Verubecestat(MK-8931) dramatically lowers CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. Due to the 20 h half-life of MK-8931 it is ideal for once-a-day dosing[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 5 mg/mL (12.21 mM), Sonication is recommended. 10% DMSO+90% Saline : < 8.33 mg/mL (20.35 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 8.33 mg/mL (20.35 mM), Solution. DMSO : 83.3 mg/mL (203.46 mM), Sonication is recommended. |
| Keywords | β-Secretase | βSecretase | Verubecestat | orally | MK8931 | MK 8931 | Inhibitor | inhibit | Disease | b-Secretase | bSecretase | Beta-secretase | BetaSecretase | BACE2 | BACE1 | BACE | Aβ40 | Alzheimer's |
| Inhibitors Related | Eslicarbazepine Acetate | Auraptene | Se-Methylselenocysteine | DSS30 | Loganin | Atabecestat | LY2886721 | Phytic acid potassium | NB-360 | Timosaponin BII | Epiberberine | Tenuifolin |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Anti-Hypertension Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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