一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>Vesatolimod
Vesatolimod
  • Vesatolimod

Vesatolimod NEW

Price $45 $86 $173
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Vesatolimod CAS No.: 1228585-88-3
Purity: 98.47% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameVesatolimod
DescriptionVesatolimod (GS-9620) is an effective and specific orally active agonist of Toll-like receptor 7.
Cell ResearchGS-9620 is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. Daudi cells are incubated for indicated times with varying concentrations [3H]GS-9620 (0.7μCi/mL). Cell associated radioactivity is extracted with ice cold 80% ethanol and measured using liquid scintillation counting. The total amount of GS-9620 in cells is calculated from a calibration curve for GS-9620 mass versus radioactivity. Cell volume is measured[1].
Kinase AssayBiochemical assays: Biochemical assays are performed by a broad-coverage, TR-FRET-based kinase binding assay platform.
In vitroVesatolimod rapidly internalizes into cells and preferentially localizes to and signals from endo-lysosomal compartments. To test this hypothesis, the kinetics of cellular uptake of the compound in Daudi cells using tritiated Vesatolimod (3H-Vesatolimod) is measured. The kinetics of 3H-Vesatolimod accumulation is rapid, reaching concentration-dependent steady-state equilibrium in approximately thirty minutes. Measured intracellular concentration of 3H-Vesatolimod is 5-fold higher than the extracellular concentration of 3H-Vesatolimod used to treat cells. Increases in intracellular 3H-Vesatolimod concentrations are roughly proportional with increasing concentrations of 3H-Vesatolimod[1].
In vivoAdministering single oral doses of GS-9620 at 0.3 and 1 mg/kg to uninfected chimpanzees resulted in a dose-dependent increase in serum interferon alpha (IFN-α), various cytokines/chemokines, and activation of interferon-stimulated genes (ISG) in both peripheral blood and liver tissues. Specifically, GS-9620 reached peak plasma concentrations (Cmax) of 3.6±3.5 nM at 0.3 mg/kg (n=3), 36.8±34.5 nM at 1 mg/kg (n=3), and 55.4±81.0 nM at 1 mg/kg (n=4), respectively, with peak serum interferon responses recorded 8 hours after dosing. The induced peak serum levels of IFN-α were measured at 66 pg/mL for the 0.3 mg/kg dose and 479 pg/mL for the 1 mg/kg dose. Treatment with GS-9620 at these doses also elevated ISG transcripts, specifically ISG15, OAS-1, MX1, IP-10 (CXCL10), and I-TAC (CXCL11), in peripheral blood mononuclear cells (PBMC) at the lower dose and in both PBMC and liver at the higher dose.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 4.11 mg/mL (10.01 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.44 mM), Sonication is recommended.
KeywordsVesatolimod | Toll-like Receptor (TLR) | TLR7 | TLR | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV Protease | HIV | Hepatitis C virus | Hepatitis B virus | HCVProtease | HCV Protease | HCV | HBV | GS9620 | GS 9620 | Apoptosis
Inhibitors RelatedStavudine | Aceglutamide | Emtricitabine | Urea | Tamoxifen | Cysteamine hydrochloride | Hydroxychloroquine | Lamivudine | Metronidazole | Formamide | Alginic acid | Sildenafil citrate
Related Compound LibrariesApoptosis Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Pyroptosis Compound Library | Antioxidant Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$30.00
Anhui Ruihan Technology Co., Ltd
2023-09-07
$1.00
VIP8Y
Career Henan Chemical Co
2019-08-08

TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY
宿州市| 榆社县| 同仁县| 开鲁县| 平江县| 高尔夫| 新野县| 阜平县| 百色市| 浪卡子县| 治县。| 栖霞市| 邳州市| 建瓯市| 苍南县| 西充县| 封丘县| 阳原县| 小金县| 辽宁省| 罗甸县| 静海县| 巫溪县| 德清县| 稷山县| 延边| 宣汉县| 康定县| 江门市| 霞浦县| 德江县| 平乐县| 军事| 房山区| 盈江县| 太和县| 共和县| 新绛县| 颍上县| 北海市| 渑池县|