Vorapaxar NEW
| Price | $68 | $148 | $213 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: Vorapaxar | CAS No.: 618385-01-6 |
| Purity: 99.07% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | Vorapaxar |
| Description | Vorapaxar (MK-5348) is a selective, orally active, and competitive antagonist of the plasminogen activator receptor (PAR-1) with a Ki value of 8.1 nM. Vorapaxar primarily acts by targeting PAR-1 on the platelet surface to block thrombin-induced platelet activation. Vorapaxar is suitable for use in cardiovascular disease research. |
| In vitro | Methods: Fluorescent calcium indicator Fluo-3/AM was loaded into hPAR1/CHO-K1 cells. After 10-minute preincubation with Vorapaxar, stimuli were added: FXa (0.03 U/mL), thrombin (0.003 U/mL), or PAR1 agonist SFLLRN-NH? (3 nM). Fluorescence intensity changes were monitored in real-time using FLIPR. Results: The Ca2? elevation induced by direct PAR1 activation with SFLLRN-NH? was inhibited by Vorapaxar, confirming its antagonistic effect on PAR1. [1] |
| In vivo | Methods: Eight-week-old ApoEko mice (whose platelets do not express PAR1, used to exclude platelet effects) were divided into two groups, both fed a Western diet. The experimental group received feed supplemented with Vorapaxar (10 mg/kg feed), while the control group did not, for a duration of 4 months. Results: The aortic sinus plaque area and overall aortic lipid deposition (Oil Red O staining) were significantly reduced in the Vorapaxar-treated group. [2] Methods: To investigate Vorapaxar's effects on renal function in diabetic nephropathy, male C57BL/6 mice aged 8-12 weeks were intraperitoneally injected with streptozotocin (STZ) (50 mg/kg, for 5 consecutive days) to induce type 1 diabetes. Four weeks after diabetes induction, oral administration of Vorapaxar (1.75 mg/kg) began, twice weekly for 20 weeks. Results: Diabetic mice in the control group exhibited significantly elevated urinary albumin levels. In contrast, diabetic mice treated with Vorapaxar showed no increase in urinary albumin and demonstrated significantly reduced glomerular damage. [3] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 92 mg/mL (186.77 mM), Sonication is recommended. DMSO : 257.5 mg/mL (522.76 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (10.15 mM), Sonication is recommended. |
| Keywords | Vorapaxar | Thrombin receptors | SCH-530348 | SCH530348 | ProteaseactivatedReceptor | Protease-Activated Receptor (PAR) | Proteaseactivated Receptor | Protease Activated Receptor (PAR) | PAR-1 | MK5348 | MK 5348 | Inhibitor | inhibit |
| Inhibitors Related | TRAP-6 amide acetate | Protease-Activated Receptor-1, PAR-1 Agonist acetate | PAR-2 Activating Peptide acetate | ML-354 | PAR-4 Agonist Peptide, amide TFA | Atopaxar | Vorapaxar sulfate | Trypsin | AY 77 | tcY-NH2 TFA(327177-34-4 free base) | VKGILS-NH2 Acetate | 2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) |
| Related Compound Libraries | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bitter Compound library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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