Product Details
| Product Name:
VU6007477 |
CAS No.:
2220141-46-6 |
| Purity:
99.67% |
Supply Ability:
10g |
| Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | VU6007477 |
| Description | VU6007477 is a brain-penetrant and selective M1 muscarinic receptor positive allosteric modulator (PAM) with an EC50 value of 230 nM, characterized by improved central nervous system penetration compared with hydroxylated congeners, moderate permeability as a human P-glycoprotein substrate, a pyranyl amide chemical scaffold, and strong suitability for experimental investigations into robust cholinergic seizure activity, central cholinergic signaling, and neurological disease models requiring reliable CNS exposure. |
| In vitro | Method: A series of M1 positive allosteric modulators based on a pyrrolo[2,3-b]pyridine core were generated via scaffold hopping and iterative parallel synthesis and evaluated in rat M1 receptor assays and in vivo CNS exposure and adverse event studies.
Result: Removal of a secondary hydroxyl group yielded VU6007477, which showed good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal agonist activity (agonist EC50 > 10 μM), good CNS penetration in rats and mice, and no cholinergic seizure liability[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
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Suppliers |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States