VUF 8430 dihydrobromide NEW
| Price | $37 |
| Package | 1mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: VUF 8430 dihydrobromide | CAS No.: 100130-32-3 |
| Purity: 99.90% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | VUF 8430 dihydrobromide |
| Description | VUF 8430 dihydrobromide is a potent and selective histamine H4 receptor agonist with a Ki value of 31.6 nM and an EC50 of 50 nM, commonly used in immunology and inflammation research to investigate H4 receptor–mediated signaling, immune cell chemotaxis, cytokine release, and the role of histamine in allergic and inflammatory responses. |
| In vitro | In HEK293 cells expressing the human Histamine H4 receptor (H4R), VUF 8430 dihydrobromide functioned as a full agonist with a Ki of 31 nM. It inhibited forskolin-induced cAMP accumulation and triggered calcium mobilization and MAPK phosphorylation. Furthermore, the agonist induced the chemotaxis of eosinophils and mast cells in immune cell recruitment assays [1]. |
| In vivo | In mouse models, subcutaneous injection of VUF 8430 dihydrobromide induces scratching behavior, a physiological marker of the itch response. This behavior is inhibited by selective H4 receptor antagonists, such as JNJ 7777120. These observations indicate that H4R signaling mediates histamine-induced pruritus through a pathway independent of H1 receptors [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (309.55 mM), Sonication is recommended. DMSO : <32.31 mg/mL, Sonication is recommended. |
| Keywords | VUF-8430 | VUF8430 | VUF 8430 Dihydrobromide | VUF 8430 |
| Inhibitors Related | Undecane | Betahistine mesylate | Histamine dihydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Nizatidine | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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