Wf-516 NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-23 |
Product Details
| Product Name: Wf-516 | CAS No.: 310392-94-0 |
| Supply Ability: 10g | Release date: 2025/07/23 |
Product Introduction
Bioactivity
| Name | Wf-516 |
| Description | Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activity. |
| In vitro | WF-516 exhibits high affinity for 5-HT1A receptors in the hippocampus and raphe nucleus of rats (Ki of 8.1 nM and 7.9 nM, respectively) [2]. |
| In vivo | Wf-516 (0.5 mg/kg, i.v.) does not alter the firing activity of 5-HT neurons but significantly inhibits the effect of 8-OHDPAT (a 5-HT autoreceptor agonist) by 70%. The suppression of DRN firing activity by LSD experienced a significant fourfold rightward shift in Wf-516 pretreated rats (ED50 = 32.4 ± 1.0 μg/kg) compared to controls (ED50 = 7.5 ± 1.2 μg/kg). Successive intravenous doses of Wf-516 (up to 10 mg/kg) prolong the effect of microiontophoretically applied 5-HT, achieving statistical significance at 7.5 mg/kg, with RT50 values increased by 53% and 75% at 7.5 mg/kg and 10 mg/kg, respectively. Oral administration of 30 mg/kg Wf-516 to 5,7-DHT-treated rats resulted in a significant decrease in hippocampal BPND, with no further decrease in the grooved nuclei; ED50 values were 5.3 mg/kg in the hippocampus and 4.2 mg/kg in the grooved nuclei. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Wf-516 | Wf516 | Wf 516 | Human 5-HT2A receptor | Human 5-HT1A receptor | 5HTReceptor | 5HT Receptor |
| Inhibitors Related | Serotonin hydrochloride | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | Clozapine N-Oxide | Mirtazapine | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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