Win 58237 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Win 58237 | CAS No.: 158001-76-4 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Win 58237 |
| Description | Win 58237 is an inhibitor of cyclic nucleotide phosphodiesterase (PDE) (Ki: 170 nM for PDE V), with vasorelaxant activity. |
| In vitro | Win 58237 is a competitive cGMP PDE V inhibitor from canine aorta(Ki : 170 nM). Win 58237 is a potent PDE V inhibitor isolated from vascular tissue (IC50 : 240 nM). It is a relatively less potent calmodulin-sensitive PDE I and cGMP-inhibitable cyclic AMP PDE III inhibitor ; but does inhibit cyclic AMP PDE IV with an IC50 value of approximately 300 nM. Win 58237 possesses vasorelaxant activity in the presence of an intact endothelium or nitric oxide. |
| In vivo | In vivo administration of Win 58237, at dosages ranging from 0.3 to 3.0 mg/kg intravenously, reduces mean arterial pressure in conscious spontaneously hypertensive rats, accompanied by a rise in vascular (aortic) cGMP content. Additionally, at a higher dosage of 10 mg/kg intravenously, Win 58237 elevates plasma cGMP levels from a baseline of 6.7 ± 1.0 to 31.4 ± 3.5 fmol/μL. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Win 58237 | PDE V |
| Inhibitors Related | Balipodect | Theophylline monohydrate | D(+)-Raffinose pentahydrate | Theobromine | Apremilast | Isoprenaline hydrochloride | Indomethacin | Icariin | Theophylline | Vardenafil hydrochloride | Sildenafil citrate | Doxofylline |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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