Product Details
| Product Name:
YC-001 |
CAS No.:
748778-73-6 |
| Supply Ability:
10g |
Release date:
2026/06/03 |
Product Introduction
Bioactivity
| Name | YC-001 |
| Description | YC-001 is an inverse agonist and antagonist targeting rod opsin. YC-001 binds reversibly to rod opsin, thereby stabilizing its structure and protecting mice from bright light-induced retinal degeneration, showing potential for research on retinal degenerative diseases. |
| In vitro | Methods: In vitro assays were performed using gradient concentrations of YC-001 (0–100 μM).
Results: The potency of YC-001 was 8.7 μM, with an efficacy range of 150–310%.
Methods: Samples were treated with gradient concentrations of YC-001 (0.5, 1, 5, 10, 20, 40 μM).
Results: YC-001 improved the glycosylation profile of the P23H rhodopsin mutant.
Methods: Binding assays were conducted using gradient concentrations of YC-001 (0–1.5 μM).
Results: YC-001 bound reversibly to rod opsin, with an EC50 of 0.98 μM.
Methods: NIH3T3 cells were treated with gradient concentrations of YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 μM).
Results: YC-001 dose-dependently increased intracellular cAMP levels in NIH3T3 cells. |
| In vivo | Methods: Abca4?/?Rdh8?/? mice were intraperitoneally injected with YC-001 (50, 200 mg/kg).
Results: YC-001 protected Abca4?/?Rdh8?/? mice against bright light–induced retinal degeneration.
Methods: Mice were administered YC-001 systemically via intraperitoneal injection (200 mg/kg).
Results: YC-001 could penetrate into mouse eyes after systemic administration but could not be retained for a long time.
Methods: Mice were intraperitoneally injected with YC-001 (100 mg/kg, 200 mg/kg) once daily for 24 consecutive days.
Results: YC-001 showed almost no acute toxicity[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (282.92 mM), Sonication is recommended.
|
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Guanidine thiocyanate | glycine | Malic acid | Glycerol | Thymidine | Gluconate Calcium | DL-Lysine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
-
CAS:1306761-53-4
$2120.00
-
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2500.00
|
VIP2Y
|
TargetMol Chemicals Inc.
|
2026-04-21 |
|
|
$912.00
|
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-06-08 |
|
|
$3.00
|
VIP2Y
|
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
|
2026-07-02 |
United States