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Postion:Product Catalog >YM-155 hydrochloride
YM-155 hydrochloride
  • YM-155 hydrochloride

YM-155 hydrochloride NEW

Price $178 $326 $638
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-04-21

Product Details

Product Name: YM-155 hydrochloride CAS No.: 355406-09-6
Supply Ability: 10g Release date: 2026/04/21

Product Introduction

Bioactivity

NameYM-155 hydrochloride
DescriptionSepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits the survivin promoter with an IC?? of 0.54 nM[1].
In vitroSepantronium bromide (YM155; 30 μM) does not affect survivin gene promoter-driven luciferase reporter activity but significantly suppresses endogenous survivin expression in PC-3 and PPC-1 human HRPC cells with deficient p53 by transcriptionally inhibiting the survivin gene promoter. At 100 nM, it does not impact the protein expression of c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin, and β-tubulin. Sepantronium bromide exhibits potent inhibition against various human cancer cell lines, including those with mutated or truncated p53 (e.g., PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5, and A375), with IC50 values ranging from 2.3 to 11 nM. It also increases the sensitivity of NSCLC cells to γ-radiation, enhances apoptotic cell numbers and caspase-3 activity, and delays the repair of radiation-induced double-strand breaks in nuclear DNA.
In vivoSepantronium bromide (YM155) effectively inhibits tumor growth in PC-3 xenografts at doses of 3 and 10 mg/kg without causing significant loss in body weight or reduction in blood cell count. It preferentially accumulates in tumor tissues in vivo and achieves an 80% Tumor Growth Inhibition (TGI) at a 5 mg/kg dosage in PC-3 orthotopic xenografts [1]. Additionally, when combined with γ-radiation, YM155 exhibits potent antitumor efficacy against H460 and Calu6 xenografts in nude mice [2]. In models of orthotopic renal and metastatic lung tumors, the combination of YM-155 (Sepantronium bromide) and IL-2 synergistically reduces tumor weight, lung metastases, and the visibility of luciferin-stained tumors [3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
KeywordsYM-155 Hydrochloride | YM155 Hydrochloride | YM 155 hydrochloride
Inhibitors RelatedStavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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