YM-264 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: YM-264 | CAS No.: 131888-54-5 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | YM-264 |
| Description | YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes). |
| In vitro | YM-264 inhibits [3H] platelet-activating factor binding to rabbit platelet membranes with a pKivalue of 8.85. YM-264 inhibits the platelet-activating factor-induced human, rabbit and guinea-pig platelet aggregation with pA2 values of 8.68, 8.33 and 8.14, respectively[1]. |
| In vivo | Antigen exposure-induced airway hyperresponsiveness is significantly reduced with YM-264 administration. The control group shows a baseline airway resistance (Rrs) value of 0.40 (0.02) cm H2O/mL/s (n=6), compared to YM-264 treated groups which exhibit baseline Rrs values of 0.39 (0.01) cm H2O/mL/s for 1 mg/kg (n=5) and 0.36 (0.01) cm H2O/mL/s for 3 mg/kg (n=6). During immediate allergic reactions, Rrs notably increases to 0.92 (0.10) cm H2O/mL/s in the control (p=0.0002), contrasted with lesser increases of 0.81 (0.12) cm H2O/mL/s at 1 mg/kg (p=0.01) and 1.06 (0.29) cm H2O/mL/s at 3 mg/kg (p=0.048) in the YM-264 treated groups. Furthermore, a significant re-elevation of Rrs to 0.72 (0.10) cm H2O/mL/s (p=0.0101) from baseline is observed in the control group 6 hours post-antigen challenge, whereas YM-264 at doses of 1 and 3 mg/kg markedly inhibits this rise in comparison. Additionally, YM-264 demonstrates a dose-dependent inhibition of eosinophil infiltration. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | YM-264 | YM264 | YM 264 | PAF, rabbit platelet membranes |
| Inhibitors Related | Cedrol | Ginkgolide B | PAF C-18 | (Rac)-Modipafant | CP 96021 | Rupatadine | 48740 RP | SDZ-62-434 | Rocepafant | Rupatadine Fumarate | 2-Acetylbenzoic acid | Dersalazine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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