YS-49 NEW
| Price | $41 | $56 | $92 |
| Package | 1mg | 2mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: YS-49 | CAS No.: 132836-42-1 |
| Purity: 99.65% | Supply Ability: 10g |
| Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | YS-49 |
| Description | YS-49 is an activator of PI3K/Akt (a downstream target of RhoA). |
| In vitro | In RAVSMC and RAW 264.7 cells, YS-49 (1-100?μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].At the transcriptional level, YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells [2]. |
| In vivo | In male Sprague Dawley rats,YS-49 (5mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 10 mg/mL (25.89 mM), Sonication and heating to 60℃ are recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (10.36 mM), Sonication is recommended. DMSO : 250 mg/mL (647.2 mM), Sonication is recommended. |
| Keywords | β-adrenoceptor | YS-49 | YS49 | YS 49 | Protein kinase B | PKB | PI3K | Phosphoinositide 3-kinase | Inhibitor | inhibit | Beta Receptor | Angiotensin Receptor | Akt | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Aceglutamide | Losartan potassium | Musk ketone | Stearamide | Bisphenol A | Myricetin | Hyaluronic acid | Ethyl linoleate | Methyl eugenol | 2,3-Butanediol | Diisononyl phthalate | Captopril |
| Related Compound Libraries | Glycolysis Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Alkaloid Natural Product Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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